Open AccessCardiac and Skeletal Muscle Myosin Exert Procoagulant Effects
Author(s) -
Julia R. Coleman,
Ernest E. Moore,
Jevgenia ZilbermanRudenko,
Jason M. Samuels,
Mitchell J. Cohen,
Christopher C. Silliman,
Anirban Banerjee,
Angela Sauaia,
John H. Griffin,
Hiroshi Deguchi
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001426
Subject(s) - skeletal muscle , myosin , fibrinolysis , medicine , thrombelastography , cardiac muscle , context (archaeology) , cardiology , endocrinology , coagulation , chemistry , biology , biochemistry , paleontology
Trauma-induced coagulopathy (TIC) and the tissue injury-provoked procoagulant profile are prevalent in severely injured patients, but their mechanisms remain unclear. Myosin, exposed by or released from tissue injury, may play a role in promoting thrombin generation and attenuating fibrinolysis. The objective of the study is to examine the effects of cardiac and skeletal muscle myosins on coagulation in whole blood using thrombelastography (TEG).