Open AccesssEH Inhibitor Tppu Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions
Author(s) -
Zhihui Chen,
Ying Tang,
Jing Yu,
Ruolan Dong,
Yan Yang,
Menglu Fu,
Jing Luo,
Shuiqing Hu,
Dao Wen Wang,
Lei Tu,
Xizhen Xu
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001408
Subject(s) - sepsis , epoxide hydrolase 2 , macrophage , inflammation , pharmacology , medicine , ligation , chemistry , cancer research , immunology , in vitro , biochemistry , enzyme
Sepsis is a life-threatening organ dysfunction initiated by a dysregulated response to infection, with imbalanced inflammation and immune homeostasis. Macrophages play a pivotal role in sepsis. N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea (TPPU) is an inhibitor of soluble epoxide hydrolase (sEH), which can rapidly hydrolyze epoxyeicosatrienoic acids (EETs) to the bio-inactive dihydroxyeicosatrienoic acids. TPPU was linked with the regulation of macrophages and inflammation. Here, we hypothesized that sEH inhibitor TPPU ameliorates cecal ligation and puncture (CLP)-induced sepsis by regulating macrophage functions.