Open AccessEarly Maladaptive Cardiovascular Responses are Associated with Mortality in a Porcine Model of Hemorrhagic Shock
Author(s) -
Ruth Shaylor,
Lilach Gavish,
Yaniv Gal,
Linn Wagnert-Avraham,
S. David Gertz,
Charles Weissman,
Jacob Megreli,
Gil Shimon,
Ben Simon,
A. Berman,
Arik Eisenkraft
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001401
Subject(s) - medicine , hemodynamics , blood pressure , shock (circulatory) , tachycardia , mean arterial pressure , anesthesia , cardiology , stroke volume , cardiac output , heart rate
Hemorrhage is a leading cause of death on the battlefield. Current methods for predicting hemodynamic deterioration during hemorrhage are of limited accuracy and practicality. During a study of the effects of remote ischemic preconditioning in pigs that underwent hemorrhage, we noticed arrhythmias among all pigs that died before the end of the experiment but not among surviving pigs. The present study was designed to identify and characterize the early maladaptive hemodynamic responses (tachycardia in the presence of hypotension without a corresponding increase in cardiac index or mean arterial blood pressure) and their predictive power for early mortality in this experimental model.