Open AccessClub Cell Protein, CC10, Attenuates Acute Respiratory Distress Syndrome Induced by Smoke Inhalation
Author(s) -
Ernesto Lopez,
Osamu Fujiwara,
Christielson,
Melissa E Winn,
Richard S Clayton,
Robert A. Cox,
Hal K. Hawkins,
Clark R. Andersen,
Charles E. Wade,
H. K. Hariprakasha,
Donald S. Prough,
Aprile L. Pilon,
Perenlei Enkhbaatar
Publication year - 2020
Publication title -
shock
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001365
Subject(s) - ards , medicine , smoke inhalation , inhalation , respiratory distress , anesthesia , lung , pulmonary function testing , pulmonary edema
To evaluate the dose effects of Recombinant human Club cell 10-kDa protein (rhCC10) on lung function in a well-characterized ovine model of acute respiratory distress syndrome (ARDS) induced by smoke inhalation injury (SII); specifically, the potential of rhCC10 protein to control the inflammatory response and protect pulmonary tissue and function following SII.