Open AccessMonophosphoryl Lipid a Attenuates Multiorgan Dysfunction During Post-Burn Pseudomonas Aeruginosa Pneumonia in Sheep
Author(s) -
Seisuke Fukuda,
Kenji Ihara,
Julia K. Bohan,
Antonio Hernandez,
Naeem K. Patil,
Liming Luan,
Cody L Stothers,
Ryan J. Stark,
Donald S. Prough,
David N. Herndon,
Edward R. Sherwood,
Perenlei Enkhbaatar
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001364
Subject(s) - pseudomonas aeruginosa , pneumonia , medicine , lung , anesthesia , pharmacology , biology , genetics , bacteria
Monophosphoryl lipid A (MPLA) is a TLR4 agonist that has potent immunomodulatory properties and modulates innate immune function to improve host resistance to infection with common nosocomial pathogens in mice. The goal of this study was to assess the safety and efficacy of MPLA in a sheep model of burn injury and Pseudomonas aeruginosa pneumonia. The sheep provides a favorable model for preclinical testing as their response to TLR4 agonists closely mimics that of humans.