Open AccessAcute Inflammation in Traumatic Brain Injury and Polytrauma Patients Using Network Analysis
Author(s) -
Bradley Rowland,
Jude Savarraj,
Jay Karri,
Xu Zhang,
Jessica C. Cardenas,
H. Alex Choi,
John B. Holcomb,
Charles E. Wade
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001349
Subject(s) - polytrauma , medicine , traumatic brain injury , retrospective cohort study , surgery , anesthesia , psychiatry
Traumatic brain injury (TBI) is associated with secondary injury to the central nervous system (CNS) via inflammatory mechanisms. The combination of polytrauma and TBI further exacerbates the inflammatory response to injury; however, combined injury phenomena have not been thoroughly studied. In this study, we examined the inflammatory differences between patients with TBI versus patients with polytrauma, but no TBI (polytrauma). We hypothesize that patients with TBI have a heightened early inflammatory response compared with polytrauma.