Open AccessSelenium and Selenoprotein P Deficiency Correlates With Complications and Adverse Outcome After Major Trauma
Author(s) -
Mareen Braunstein,
Thomas Kusmenkov,
Catrin Margarita Zuck,
Matthias Angstwurm,
NielsPeter Becker,
Wolfgang Böcker,
Lutz Schomburg,
Viktoria Bogner-Flatz
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001344
Subject(s) - selenoprotein , selenoprotein p , selenium , adverse outcome pathway , medicine , outcome (game theory) , adverse effect , oxidative stress , chemistry , biology , glutathione peroxidase , mathematics , organic chemistry , mathematical economics , computational biology , catalase
A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period.