Open AccessThe Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in a Rodent Model of Liver Transplantation
Author(s) -
Christoph Emontzpohl,
Christian Stoppe,
Alexander Theißen,
Christian Beckers,
Ulf Neumann,
Georg Lurje,
Cynthia Ju,
Jürgen Bernhagen,
René Tolba,
Zoltán Czigány
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001307
Subject(s) - macrophage migration inhibitory factor , ischemic preconditioning , hepatoprotection , downregulation and upregulation , medicine , liver transplantation , transplantation , reperfusion injury , pharmacology , ischemia , immunology , cytokine , chemistry , glutathione , biochemistry , gene , enzyme
Macrophage migration inhibitory factor (MIF) is an important stress-regulating mediator of acute ischemia/reperfusion (I/R) injury and ischemic conditioning. The present study aimed to investigate whether MIF is involved in the effects of remote ischemic conditioning (RIC) in a rat model of orthotopic liver transplantation (OLT).