Open AccessBurn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice
Author(s) -
Li Ma,
Yangfan Zhou,
Mohammed A S Khan,
Shingo Yasuhara,
J. A. Jeevendra Martyn
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001300
Subject(s) - microglia , motor neuron , proinflammatory cytokine , neuroinflammation , muscle atrophy , medicine , skeletal muscle , neuroscience , inflammation , spinal cord , endocrinology , biology
Burn injury (BI) leads to both systemic and neuro-inflammation and is associated with muscle wasting and weakness, which increase morbidity and mortality. Disuse atrophy is concomitantly present in BI patients. Most studies have focused on muscle with little attention to role of central nervous system (CNS) in the neuromuscular changes. We tested the hypothesis that BI-induced muscle wasting stems from CNS microglia activation and cytokines and chemokine release, which is associated with spinal ventral horn motor neuron degeneration.