Open AccessDexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome
Author(s) -
Yan Geng,
Li Ru,
Songqing He,
Hee Chul Yang,
Qiaoting Deng,
Xiangyang Shao,
Yanni Wu,
Weiwen Xu,
Qiang Ma
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001289
Subject(s) - bronchoalveolar lavage , tlr4 , medicine , pharmacology , lung , dexmedetomidine , proinflammatory cytokine , downregulation and upregulation , nf κb , inflammation , anesthesia , immunology , chemistry , biochemistry , sedation , gene
Dexmedetomidine (DEX) has been demonstrated to inhibit inflammatory response and protect against multiorgan injury in various scenarios. The objectives of the present study were to ascertain whether DEX is able to attenuate acute lung injury (ALI) under heatstroke (HS), and to explore the underlying mechanism.