Open AccessEffect of Coagulation Factor Concentrates on Markers of Endothelial Cell Damage in Experimental Hemorrhagic Shock
Author(s) -
Nikolaus Hofmann,
Johannes Zipperle,
Florian Brettner,
Mohammad Jafarmadar,
Mostafa Ashmwe,
Claudia Keibl,
Martin Ponschab,
Ulrike Kipman,
Arian Bahrami,
Heinz Redl,
Soheyl Bahrami,
Valentin Fuhrmann,
Herbert Schöchl
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001286
Subject(s) - resuscitation , medicine , syndecan 1 , mean arterial pressure , coagulation , glycocalyx , shock (circulatory) , anesthesia , andrology , chemistry , immunology , blood pressure , biochemistry , cell , heart rate
Plasma-based resuscitation showed protective effects on the endothelial glycocalyx compared with crystalloid resuscitation. There is paucity of data regarding the effect of coagulation factor concentrates (CFC) on the glycocalyx in hemorrhagic shock (HS). We hypothesized that colloid-based resuscitation supplemented with CFCs offers a therapeutic value to treat endothelial damage following HS.