Open AccessPlasma Renin Concentration is Associated With Hemodynamic Deficiency and Adverse Renal Outcome in Septic Shock
Author(s) -
Maxime Nguyen,
Damien Denimal,
Auguste Dargent,
Pierre-Grégoire Guinot,
Laurence Duvillard,
JeanPierre Quenot,
Bélaïd Bouhemad
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001285
Subject(s) - plasma renin activity , natriuresis , septic shock , medicine , renin–angiotensin system , effective renal plasma flow , hemodynamics , endocrinology , renal blood flow , shock (circulatory) , renal function , blood pressure , sepsis
In septic shock, both systemic vasodilatation and glomerular arteriole dilatation are responsible for the drop in glomerular filtration observed in early acute kidney injury. Angiotensin II has been shown to act on both mechanisms. Our objective was to evaluate the impact of renin angiotensin system activation, on hemodynamic deficiency and renal outcome in patient with septic shock and to assess whether urinary sodium could be a reliable test for high plasma renin concentration screening.