Open AccessSingle Low Dose of Human Recombinant Antithrombin (ATryn) has no Impact on Endotoxin-Induced Disseminated Intravascular Coagulation: An Experimental Randomized Open Label Controlled Study
Author(s) -
Thibault Duburcq,
Arthur Durand,
Antoine Tournoys,
Viviane Gnemmi,
Caroline Bonner,
Valéry Gmyr,
Thomas Hübert,
François Pattou,
M. Jourdain
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001274
Subject(s) - disseminated intravascular coagulation , medicine , fibrinogen , von willebrand factor , antithrombin , coagulation , recombinant dna , septic shock , hemostasis , sepsis , hemodynamics , shock (circulatory) , platelet , gastroenterology , immunology , heparin , biology , biochemistry , gene
Antithrombin (AT) III physiological levels are decreased during septic shock and supplementation therapy could therefore be beneficial.