Open AccessManipulating the Microcirculation in Sepsis – the Impact of Vasoactive Medications on Microcirculatory Blood Flow: A Systematic Review
Author(s) -
Elizabeth Potter,
Luke Hodgson,
Ben CreaghBrown,
Lui G. Forni
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001239
Subject(s) - medicine , microcirculation , terlipressin , sepsis , observational study , norepinephrine , septic shock , intensive care medicine , randomized controlled trial , cardiology , ascites , hepatorenal syndrome , dopamine
Sepsis is life-threatening organ dysfunction because of a dysregulated host response to infection. Disturbed microvascular blood flow is associated with excess mortality and is a potential future target for interventions. This review addresses the evidence for pharmacological manipulation of the microcirculation in sepsis assessed by techniques that evaluate the sublingual microvasculature.