Open AccessAlterations in Mitochondrial Function in Blood Cells Obtained From Patients With Sepsis Presenting to an Emergency Department
Author(s) -
David H. Jang,
Clinton J Orloski,
Shawn Owiredu,
Frances S. Shofer,
John C. Greenwood,
David M. Eckmann
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001208
Subject(s) - sepsis , medicine , septic shock , organ dysfunction , emergency department , pathophysiology , shock (circulatory) , sofa score , prospective cohort study , respiration , psychiatry , anatomy
Mitochondrial dysfunction has been implicated as a key cellular event leading to organ dysfunction in sepsis. Our objective is to measure changes in mitochondrial bioenergetics in subjects with early presentation of sepsis to provide insight into the incompletely understood pathophysiology of the dysregulated host response in sepsis.