Open AccessAngiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium
Author(s) -
Richard W. Pierce,
Veronika Shabanova,
Michael F. Canarie,
Mathew Pinto,
Yong Sing Da Silva,
Vineet Bhandari,
John S. Giuliano
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001172
Subject(s) - sepsis , septic shock , medicine , systemic inflammatory response syndrome , angiopoietin , prospective cohort study , pathophysiology , vascular permeability , shock (circulatory) , immunology , gastroenterology , vascular endothelial growth factor , vegf receptors
Angiopoietins are postulated diagnostic biomarkers in children and adults with severe sepsis and septic shock. The diagnostic value of angiopoietins in children less than 5 years old has not been established, nor has their effect on permeability in the capillary microvasculature. We aim to determine if levels of angiopoietin-1 or -2 (angpt-1, -2) are diagnostic for severe sepsis/shock in young children and whether they affect the permeability of cultured human dermal microvascular endothelial cells (HDMEC).