Open AccessAlkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery
Author(s) -
Jesse Davidson,
Tracy T Urban,
Suhong Tong,
Aline B Maddux,
G. F. Hill,
Benjamin S. Frank,
John D. Watson,
James Jaggers,
Eric A. F. Simões,
Paul E. Wischmeyer
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001162
Subject(s) - cardiopulmonary bypass , medicine , ex vivo , alkaline phosphatase , in vivo , prospective cohort study , cardiac surgery , anesthesia , intensive care unit , gastroenterology , chemistry , biology , biochemistry , enzyme , microbiology and biotechnology
Infant cardiopulmonary bypass (CPB) increases intestinal permeability leading to endotoxemia. Alkaline phosphatase (AP) reduces endotoxin toxicity in vitro but its effects on endotoxemia in human disease are poorly understood. We assessed the association between serum AP activity and endotoxemia in infants undergoing CPB and determined the effect of ex vivo addition of AP on endotoxemia.