Open AccessGTS-21 Reduces Inflammation in Acute Lung Injury by Regulating M1 Polarization and Function of Alveolar Macrophages
Author(s) -
Jing Wang,
Ruiting Li,
Zhiyong Peng,
Wenhai Zhou,
Bo Hu,
Xiaolan Rao,
Xiao Yang,
Jianguo Li
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001144
Subject(s) - adoptive cell transfer , lipopolysaccharide , immunology , cholinergic , proinflammatory cytokine , medicine , inflammation , lung , agonist , receptor , chemistry , pharmacology , t cell , immune system
Acute lung injury (ALI) is a severe outcome of sepsis. Alveolar macrophages (AMs) play key roles in defense, resolution in ALI. The polarization of AMs is dependent on micro environmental stimuli and might influence the progression of ALI. Gainesville Tokushima scientists (GTS)-21, a selective α7 nicotinic acetylcholine receptor agonist of the cholinergic anti-inflammatory pathway (CAP), has recently been established to be promising in the treatment of ALI. However, the molecular mechanism underlying the GTS-21-mediated suppression of inflammatory responses has been explored only partially. In this study, we examined the relation between GTS-21 and AM polarization in ALI.