Open AccessActivation of Sigma-1 Receptor by Cutamesine Attenuates Neuronal Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in a Rat Model of Asphyxia Cardiac Arrest
Author(s) -
Jiahong Qin,
Peng Wang,
Yang Li,
Lan Yao,
Yuanshan Liu,
Tao Yu,
Jie Lin,
Xiangshao Fang,
Zitong Huang
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001119
Subject(s) - endoplasmic reticulum , anesthesia , sigma 1 receptor , medicine , agonist , chemistry , pharmacology , endocrinology , receptor , biochemistry
Global cerebral ischemic/reperfusion (I/R) injury after cardiac arrest (CA) is a major cause of mortality and morbidity in survivors of resuscitation. We utilized a rat model of asphyxia CA to explore the functional effects and mechanisms of Sigma-1 receptor (Sig-1R) activation in cerebral protection using the Sig-1R agonist cutamesine (SA-4503).