Open AccessHydrogen Inhalation is Superior to Mild Hypothermia for Improving Neurological Outcome and Survival in a Cardiac Arrest Model of Spontaneously Hypertensive Rat
Author(s) -
Gang Chen,
Bihua Chen,
Chenxi Dai,
Jianjie Wang,
Juan Wang,
Yuanyuan Huang,
Yongqin Li
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001092
Subject(s) - medicine , hypothermia , resuscitation , ventricular fibrillation , cardiopulmonary resuscitation , anesthesia , return of spontaneous circulation , inhalation , troponin i , cardiology , myocardial infarction
Postcardiac arrest syndrome is the consequence of whole-body ischemia-reperfusion events that lead to multiple organ failure and eventually to death. Recent animal studies demonstrated that inhalation of hydrogen greatly mitigates postresuscitation myocardial dysfunction and brain injury. However, the influence of underlying heart disease on the efficacy of hydrogen is still unknown. In the present study, we investigated the effects of hydrogen inhalation on neurological outcome and survival in a cardiac arrest model of spontaneously hypertensive rat (SHR).