Open AccessThrombin Provokes Degranulation of Platelet α-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1)
Author(s) -
Benjamin R. Huebner,
Ernest E. Moore,
Hunter B. Moore,
Gregory R. Stettler,
Geoffrey R. Nunns,
Peter J. Lawson,
Angela Sauaia,
Marguerite Kelher,
Anirban Banerjee,
Christopher C. Silliman
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001089
Subject(s) - thrombin , degranulation , fibrinolysis , platelet , chemistry , lysis , platelet activation , plasminogen activator , tissue plasminogen activator , plasminogen activator inhibitor 1 , platelet poor plasma , whole blood , pharmacology , immunology , medicine , biochemistry , receptor
The balance of fibrinolytic mediators is crucial to the survival of the critically ill patient, with tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) playing significant roles. While elevated levels of PAI-1 are associated with increased morbidity and mortality, the source of this PAI-1 remains elusive. Platelets contain 90% of circulating plasma PAI-1, however, their ability to release active PAI-1 is controversial. We hypothesize platelets contain active PAI-1 in α-granules capable of immediate degranulation when exposed to high concentrations of thrombin.