Open AccessTemporally Distinct Regulation of Pathways Contributing to Cardiac Proteostasis During the Acute and Recovery Phases of Sepsis
Author(s) -
Kristen T. Crowell,
Samantha Moreno,
Jennifer L. Steiner,
Catherine S. Coleman,
David I. Soybel,
Charles H. Lang
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001084
Subject(s) - inflammasome , sepsis , proteostasis , signal transduction , inflammation , apoptosis , microbiology and biotechnology , biology , medicine , chemistry , biochemistry
Cardiac dysfunction is a common manifestation of sepsis and is associated with early increases in inflammation and decreases in myocardial protein synthesis. However, little is known regarding the molecular mechanisms regulating protein homeostasis during the recovery phase after the removal of the septic nidus. Therefore, the purpose of this study was to investigate diverse signal transduction pathways that regulate myocardial protein synthesis and degradation.