Open AccessMuramyl Dipeptide Enhances Thermal Injury-Induced Autophagy and Inflammatory Cytokine Response of Lungs via Activation of NOD2/Rick Signaling Pathway in Rats
Author(s) -
Xiaojing Wu,
Hui Liang,
Ying Zhang,
Xu-Ming Yang,
Hongyu Wang,
Hui Li,
Xinyi Li,
Kai Chen,
Yanlin Wang,
Jianguo Li,
Zongze Zhang,
Xuemin Song
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001077
Subject(s) - muramyl dipeptide , proinflammatory cytokine , autophagy , nod2 , cytokine , chemistry , pharmacology , inflammation , medicine , receptor , immunology , innate immune system , biochemistry , immune system , apoptosis
Nucleotide-binding oligomerization domain 2 (NOD2) is the innate receptor of muramyl dipeptide (MDP). Our previous study revealed that MDP could enhance thermal injury-induced inflammatory cytokine production and organ function injury in rats. The present study was to determine the effect of MDP on autophagy and NOD2/receptor-interacting serine/threonine protein kinases (RICK) signaling pathway of lung injury after thermal injury.