Open AccessDevelopment of Noninvasive in Vivo Approach to Assess Vascular Permeability in Inflammation Using Fluorescence Imaging
Author(s) -
Takashi Shimazui,
Takaaki Nakada,
Lisa Fujimura,
Akemi Sakamoto,
Masahiko Hatano,
Shigeto Oda
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001075
Subject(s) - evans blue , vascular permeability , lung , medicine , in vivo , permeability (electromagnetism) , pathology , inflammation , fluorescence , nuclear medicine , chemistry , biology , biochemistry , physics , microbiology and biotechnology , quantum mechanics , membrane
In vivo fluorescence imaging can quantify vascular permeability without requiring sacrifice of animals. However, use of this noninvasive approach for vascular permeability assessment in remote organ injury caused by systemic inflammatory disease has not been reported.