Open AccessApplying Positive End-Expiratory Pressure During Mechanical Ventilation Causes Pulmonary Redox Imbalance and Inflammation in Rats
Author(s) -
Mônica Campos Andrade,
Ana Beatriz Farias de Souza,
Jacques Gabriel Álvares Horta,
Guilherme de Paula Costa,
André Talvani,
Sílvia Dantas Cangussú,
Rodrigo Cunha Alvim de Menezes,
Frank Silva Bezerra
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001072
Subject(s) - bronchoalveolar lavage , inflammation , lung , positive end expiratory pressure , chemistry , glutathione , medicine , superoxide dismutase , endocrinology , oxidative stress , anesthesia , biochemistry , enzyme
Mechanical ventilation (MV) may induce or aggravate lung injury through the production of cytokines, inflammatory infiltration of neutrophils, and changes in the permeability of the alveolar-capillary barrier. The use of positive end-expiratory pressure (PEEP) helps improve gas exchanges avoiding alveolar collapse at the end of expiration. The present study aimed to analyze inflammatory response and redox imbalance in lungs of rats submitted to MV with and without PEEP.