Open AccessDirect Peritoneal Resuscitation Alters Leukocyte Infiltration in the Lung After Acute Brain Death
Author(s) -
Jessica L. Weaver,
Paul J. Matheson,
Amy Matheson,
Cynthia D. Downard,
R. Neal Garrison,
Jason W. Smith
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001069
Subject(s) - medicine , inflammation , infiltration (hvac) , lung , resuscitation , proinflammatory cytokine , pathology , systemic inflammation , anesthesia , physics , thermodynamics
Brain death is associated with significant lung injury and inflammation. This has been associated with worse long-term outcomes for transplanted lungs. Direct peritoneal resuscitation (DPR) reduces systemic inflammation in brain death and improves lung procurement rate. The effect of DPR on macrophage and neutrophil infiltration in the lungs is not known.