Open AccessGlycocalyx Shedding is Enhanced by Age and Correlates with Increased Fluid Requirement in Patients with Major Burns
Author(s) -
Akinori Osuka,
Hirofumi Kusuki,
Kan Yoneda,
Hiroshi Mizunuma,
Hisatake Matsumoto,
Hiroshi Ogura,
Masashi Ueyama
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001028
Subject(s) - glycocalyx , medicine , convalescence , burn injury , gastroenterology , resuscitation , anesthesia , surgery , immunology
Massive fluid shift after severe burn injury leads to edema and intravascular fluid loss that may result in burn-induced compartment syndrome (BICS) when corrected by aggressive fluid resuscitation. Factors causing this fluid shift remain unclear. Because glycocalyx regulates endothelial permeability, we hypothesized that glycocalyx shedding would increase fluid requirements in burn patients. This prospective cohort study aimed to identify relationships between shedding of the glycocalyx and fluid requirements after burn injury.