Open AccessLPS-Induced Systemic Inflammation Does Not Alter Atherosclerotic Plaque Area or Inflammation in APOE3∗LEIDEN Mice in the Early Phase Up to 15 Days
Author(s) -
Wessel W. Fuijkschot,
Martine C. Morrison,
Ilse P.A. Zethof,
Paul A.J. Krijnen,
Robert Kleemann,
Hans W.M. Niessen,
Yvo M. Smulders
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001026
Subject(s) - inflammation , medicine , systemic inflammation , saline , intraperitoneal injection , pathology , immunology
Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether lipopolysaccharides (LPS)-evoked acute systemic inflammation would induce such detrimental vascular changes in murine aortas with manifest atherosclerotic lesions.