Open AccessPretreatment With Argon Protects Human Cardiac Myocyte-Like Progenitor Cells from Oxygen Glucose Deprivation-Induced Cell Death by Activation of AKT and Differential Regulation of Mapkinases
Author(s) -
Hong Qi,
Lourdes Soto-Gonzalez,
Konstantin A. Krychtiuk,
Sarah Ruhittel,
Christoph Kaun,
Walter S. Speidl,
Attila Kiss,
Bruno K. Podesser,
Shanglong Yao,
Klaus Markstaller,
Klaus Ulrich Klein,
Verena Tretter
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000998
Subject(s) - protein kinase b , tunel assay , apoptosis , chemistry , protein kinase a , mapk/erk pathway , reactive oxygen species , terminal deoxynucleotidyl transferase , kinase , lactate dehydrogenase , microbiology and biotechnology , biochemistry , biology , enzyme
The noble gas argon induces cardioprotection in a rabbit model of myocardial ischemia and reperfusion. However, no studies in human primary cells or subjects have been performed so far. We used human cardiac myocyte-like progenitor cells (HCMs) to investigate the protective effect on the cellular level.