Open AccessFms-Like Tyrosine Kinase-3 Ligand Attenuates Local and Systemic Infection in a Model of Post-Burn Pneumonia
Author(s) -
Gabriel Hundeshagen,
Weihua Cui,
Lindsay Musgrove,
Aaron Cherry,
Seung-Jin Lee,
Robert A. Cox,
Tracy ToliverKinsky
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000964
Subject(s) - medicine , systemic inflammation , sepsis , bacteremia , spleen , inflammation , myeloperoxidase , immunology , pneumonia , immunosuppression , lung , antibiotics , biology , microbiology and biotechnology
Burn injury induces immunosuppression and promotes infection with opportunistic pathogens. Pneumonia and sepsis are leading causes of post-burn morbidity and mortality. Fms-like tyrosine kinase-3 ligand (Flt3L) improves local and systemic resistance to P aeruginosa-associated burn wound infection. This study evaluates the effects of post-burn prophylactic Flt3L treatment on local and systemic infection and inflammation in a murine model of pneumonia and sepsis.