Open AccessThe Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model
Author(s) -
Anne Slaughter,
Geoffrey R. Nunns,
Angelo D’Alessandro,
Anirban Banerjee,
Kirk C. Hansen,
Ernest E. Moore,
Christopher C. Silliman,
Travis Nemkov,
Hunter B. Moore,
Miguel Fragoso,
Kiara Leasia,
Erik D. Peltz
Publication year - 2018
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000948
Subject(s) - urea cycle , resuscitation , metabolite , metabolomics , metabolome , pentose phosphate pathway , glutathione , metabolism , chemistry , glycolysis , pharmacology , biochemistry , medicine , surgery , chromatography , amino acid , arginine , enzyme
The metabolic consequences of trauma induce significant clinical pathology. In this study, we evaluate the independent, metabolic contributions of tissue injury (TI) and combined tissue injury and hemorrhagic shock (TI/HS) using mass spectrometry (MS) metabolomics in a controlled animal model of critical injury.