Open AccessThe Protective Role of Curcumin in Zymosan-Induced Multiple Organ Dysfunction Syndrome in Mice
Author(s) -
Sushun Liu,
Jingyao Zhang,
Qing Pang,
Siyuan Song,
Runchen Miao,
Wei Chen,
Yanyan Zhou,
Chang Liu
Publication year - 2016
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000502
Subject(s) - zymosan , curcumin , saline , multiple organ dysfunction syndrome , oxidative stress , pharmacology , chemistry , medicine , immunology , biochemistry , sepsis , in vitro
Multiple Organ Dysfunction Syndrome (MODS) is characterized as progressive and uncontrolled inflammatory response which involves activation of inflammatory cascades, cytokines release, and endothelial dysfunction, leading to deterioration of several organ functions. Curcumin is a natural polyphenol related to the yellow color of turmeric and has been reported to exert an anti-inflammatory, anti-oxidative, and anti-tumor effect. We conducted the study to investigate the effects of curcumin in non-septic MODS caused by zymosan in mice model.