Open AccessPulmonary Manifestations of Common Variable Immunodeficiency
Author(s) -
Tami J. Bang,
James H. Richards,
Amy L. Olson,
Steve D. Groshong,
Erwin W. Gelfand,
David A. Lynch
Publication year - 2018
Publication title -
journal of thoracic imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 57
eISSN - 1536-0237
pISSN - 0883-5993
DOI - 10.1097/rti.0000000000000350
Subject(s) - common variable immunodeficiency , medicine , interstitial lung disease , disease , lymphoma , lung , bronchiectasis , pathology , immunodeficiency , immunology , immune system , antibody
Common variable immunodeficiency (CVID) is associated with significant chronic lung disease. The purpose of this paper was to describe the clinical, radiologic, and pathologic findings of CVID-associated lung diseases. These include airways' disease, interstitial lung disease, lymphoma, and mucosa-associated lymphoid tissue lymphoma. In addition, a genetic syndrome termed Kabuki syndrome results in CVID-like immune abnormalities. These patients may also present with CVID-associated lung disease. Awareness and precise identification of CVID-associated lung disease may allow for better assessment of prognosis and direction of therapy.