Open AccessMolecular Imaging in Cardiovascular Magnetic Resonance Imaging
Author(s) -
David E. Sosnovik
Publication year - 2008
Publication title -
topics in magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 53
eISSN - 1536-1004
pISSN - 0899-3459
DOI - 10.1097/rmr.0b013e318176c57b
Subject(s) - magnetic resonance imaging , molecular imaging , magnetic resonance spectroscopic imaging , nuclear magnetic resonance , gadolinium , superparamagnetism , in vivo , biomedical engineering , medicine , materials science , radiology , biology , physics , magnetization , magnetic field , microbiology and biotechnology , quantum mechanics , metallurgy
The development of novel imaging agents and techniques is allowing some biological events to be imaged in vivo with magnetic resonance imaging (MRI) at the cellular and subcellular level. In this paper, the use of novel gadolinium chelates and superparamagnetic iron oxide nanoparticles for molecular MRI of the cardiovascular system is extensively reviewed. The physical properties of these imaging agents and the pulse sequences best suited to their visualization are extensively discussed. The application of molecular MRI in diseases of the vasculature and myocardium is then reviewed. The clinical experience to date, as well as the promise and potential impact of molecular MRI, is extensively discussed.