Open AccessReperfusion Therapies for Children With Arterial Ischemic Stroke
Author(s) -
Jeremy J Heit,
Prakash Muthusami,
Ronil V. Chandra,
Ferdinand Hui,
Matías Negrotto,
Sarah Lee,
Bruce A. Wasserman,
Todd Abruzzo
Publication year - 2021
Publication title -
topics in magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 53
eISSN - 1536-1004
pISSN - 0899-3459
DOI - 10.1097/rmr.0000000000000273
Subject(s) - medicine , thrombolysis , dosing , clinical trial , arterial ischemic stroke , stroke (engine) , intensive care medicine , pediatric stroke , ischemic stroke , physical therapy , ischemia , mechanical engineering , myocardial infarction , engineering
Modern hyperacute reperfusion therapies including intravenous thrombolysis and mechanical thrombectomy have transformed the management of arterial ischemic stroke (AIS) in adults. Multiple randomized clinical trials have demonstrated that these therapies enable remarkable improvements in clinical outcome for properly selected patients with AIS. Because pediatric patients were excluded from predicate clinical trials, there is a conspicuous lack of data to guide selection of therapies and inform age-adjusted and pathology-oriented treatment modifications for children. Specifically, technical guidance concerning treatment eligibility, drug dosing, and device implementation is lacking. This review aims to outline important features that differentiate pediatric AIS from adult AIS and provide practical strategies that will assist the stroke specialist with therapeutic decision making.