Open AccessImaging of Tumor Hypoxia With 18F-EF5 PET/MRI in Cervical Cancer
Author(s) -
Sara Narva,
Marko Seppänen,
Juho Raiko,
Sarita Forsbäck,
Katri J. Orte,
Johanna Virtanen,
Johanna Hynninen,
Sakari Hietanen
Publication year - 2021
Publication title -
clinical nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.637
H-Index - 57
eISSN - 1536-0229
pISSN - 0363-9762
DOI - 10.1097/rlu.0000000000003914
Subject(s) - medicine , hypoxia (environmental) , immunohistochemistry , tumor hypoxia , pathology , positron emission tomography , biopsy , nuclear medicine , radiology , chemistry , radiation therapy , oxygen , organic chemistry
The aim of this study was to evaluate the distribution of hypoxia using 18F-EF5 as a hypoxia tracer in cervical cancer patients with PET/MRI. We investigated the association between this 18F-EF5-PET tracer and the immunohistochemical expression of endogenous hypoxia markers: HIF1α, CAIX, and GLUT1.