Open AccessMonoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis
Author(s) -
Tetsuro Tago,
Jun Toyohara,
Renpei Sengoku,
Shigeo Murayama,
Kenji Ishii
Publication year - 2019
Publication title -
clinical nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.637
H-Index - 57
eISSN - 1536-0229
pISSN - 0363-9762
DOI - 10.1097/rlu.0000000000002564
Subject(s) - gliosis , monoamine oxidase b , medicine , monoamine oxidase , pathology , lesion , basal ganglia , central nervous system , biochemistry , enzyme , chemistry
An 86-year-old woman with cognitive impairment and left hemiparesis underwent F-THK5351 PET 4 months before her death. In addition to "normal" off-target binding in the basal ganglia, abnormal accumulation was observed along the pyramidal tract and around the right basal ganglia as ring-shaped uptake that overlapped a gadolinium-enhanced lesion. Postmortem pathological examination revealed that she had glioblastoma multiforme with associated gliosis, in which monoamine oxidase B (MAO-B) activity is increased. In vitro autoradiography of the corresponding lesion demonstrated specific binding of F-THK5351, which was blocked by an MAO-B-selective ligand. Thus, F-THK5351 PET may reflect glioblastomas and associated gliosis by binding to MAO-B.