Open AccessIn Vivo Characterization of Changing Blood-Tumor Barrier Permeability in a Mouse Model of Breast Cancer Metastasis
Author(s) -
Dean B. Percy,
Emeline J. Ribot,
Yuhua Chen,
Catherine McFadden,
Carmen Simedrea,
Patricia S. Steeg,
Ann F. Chambers,
Paula J. Foster
Publication year - 2011
Publication title -
investigative radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1536-0210
pISSN - 0020-9996
DOI - 10.1097/rli.0b013e318226c427
Subject(s) - in vivo , brain metastasis , permeability (electromagnetism) , breast cancer , metastasis , magnetic resonance imaging , blood–brain barrier , medicine , pathology , ex vivo , cancer research , cancer , chemistry , central nervous system , biology , radiology , biochemistry , microbiology and biotechnology , membrane
The current lack of efficacy for any chemo- or molecular therapeutic in the treatment of brain metastases is thought to be due, in part, to the heterogeneous permeability of the blood-brain-barrier (BBB). Little is known about how heterogeneous permeability develops, or how it varies among individual metastases. Understanding the BBB's role in metastasis will be crucial to the development of new, more effective therapies. In this article, we developed the first magnetic resonance imaging-based strategy to detect and measure the volumes of BBB permeable and nonpermeable metastases and studied the development of altered BBB permeability in metastases in vivo, over time in a mouse model of breast cancer metastasis to the brain.