Open AccessSafety and Gadolinium Distribution of the New High-Relaxivity Gadolinium Chelate Gadopiclenol in a Rat Model of Severe Renal Failure
Author(s) -
Nathalie Fretellier,
Marlène Rasschaert,
Julien Bocanegra,
Philippe Robert,
Cécile Factor,
Aymeric Seron,
JeanMarc Idée,
Claire Corot
Publication year - 2021
Publication title -
investigative radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1536-0210
pISSN - 0020-9996
DOI - 10.1097/rli.0000000000000793
Subject(s) - gadodiamide , gadolinium , nephrogenic systemic fibrosis , gadobutrol , medicine , nuclear medicine , kidney , chemistry , histopathology , pathology , urology , organic chemistry
The aim of this study was to investigate the toxicological profile of gadopiclenol, a new high-relaxivity macrocyclic gadolinium-based contrast agent (GBCA), in renally impaired rats, in comparison with 2 other macrocyclic GBCAs, gadoterate meglumine and gadobutrol, and 1 linear and nonionic GBCA, gadodiamide.