Open AccessMolecular Magnetic Resonance Imaging of Liver Fibrosis and Fibrogenesis Is Not Altered by Inflammation
Author(s) -
Diêgo S. Ferreira,
Gunisha Arora,
Richard L. Gieseck,
Nicholas J. Rotile,
Philip A. Waghorn,
Kenneth K. Tanabe,
Thomas A. Wynn,
Peter Caravan,
Bryan C. Fuchs
Publication year - 2020
Publication title -
investigative radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1536-0210
pISSN - 0020-9996
DOI - 10.1097/rli.0000000000000737
Subject(s) - fibrosis , inflammation , schistosoma mansoni , hepatic fibrosis , pathology , schistosoma japonicum , extracellular matrix , magnetic resonance imaging , medicine , biology , immunology , schistosomiasis , microbiology and biotechnology , radiology , helminths
Three groups of mice that develop either mild type 2 inflammation and fibrosis (wild type), severe fibrosis with exacerbated type 2 inflammation (Il10-/-Il12b-/-Il13ra2-/-), or minimal fibrosis with marked type 1 inflammation (Il4ra∂/∂) after infection with S. mansoni were imaged using both probes for determination of signal enhancement. Schistosoma mansoni-infected wild-type mice developed chronic liver fibrosis.