Open AccessIn Vivo Aortic Magnetic Resonance Elastography in Abdominal Aortic Aneurysm
Author(s) -
Haitao Dong,
Duncan S. Russell,
Alan S. Litsky,
Matthew Joseph,
Xiaokui Mo,
Richard D. White,
Arunark Kolipaka
Publication year - 2020
Publication title -
investigative radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1536-0210
pISSN - 0020-9996
DOI - 10.1097/rli.0000000000000660
Subject(s) - magnetic resonance elastography , elastin , abdominal aortic aneurysm , aortic aneurysm , aorta , medicine , magnetic resonance imaging , stiffness , aneurysm , materials science , ultimate tensile strength , elastography , cardiology , radiology , pathology , ultrasound , composite material
Using maximum diameter of an abdominal aortic aneurysm (AAA) alone for management can lead to delayed interventions or unnecessary urgent repairs. Abdominal aortic aneurysm stiffness plays an important role in its expansion and rupture. In vivo aortic magnetic resonance elastography (MRE) was developed to spatially measure AAA stiffness in previous pilot studies and has not been thoroughly validated and evaluated for its potential clinical value. This study aims to evaluate noninvasive in vivo aortic MRE-derived stiffness in an AAA porcine model and investigate the relationships between MRE-derived AAA stiffness and (1) histopathology, (2) uniaxial tensile test, and (3) burst testing for assessing MRE's potential in evaluating AAA rupture risk.