Open AccessMolecular Magnetic Resonance Imaging of Fibrin Deposition in the Liver as an Indicator of Tissue Injury and Inflammation
Author(s) -
Iliyana P. Atanasova,
Mozhdeh Sojoodi,
Helena S. Leitão,
Sergey Shuvaev,
Carlos F. G. C. Geraldes,
Ricard Masia,
Alexander S. R. Guimaraes,
Kenneth K. Tanabe,
Bryan C. Fuchs,
Peter Caravan
Publication year - 2019
Publication title -
investigative radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1536-0210
pISSN - 0020-9996
DOI - 10.1097/rli.0000000000000631
Subject(s) - inflammation , fibrin , fibrosis , magnetic resonance imaging , medicine , pathology , liver injury , gastroenterology , immunology , radiology
Liver inflammation is associated with nonalcoholic steatohepatitis and other pathologies, but noninvasive methods to assess liver inflammation are limited. Inflammation causes endothelial disruption and leakage of plasma proteins into the interstitial space and can result in extravascular coagulation with fibrin deposition. Here we assess the feasibility of using the established fibrin-specific magnetic resonance probe EP-2104R for the noninvasive imaging of fibrin as a marker of liver inflammation.