Open AccessAssociation of Dickkopf-1 Polymorphisms With Radiological Damage and Periodontal Disease in Patients With Early Rheumatoid Arthritis
Author(s) -
Alex Darío Cardona-Rincón,
M. Acevedo-Godoy,
Juan Manuel Bello-Gualtero,
Rafael Valle-Oñate,
Philippe Chalem-Choueka,
Sandra J. Perdomo,
Angela Miyared Arias-Arias,
Lorena Chila-Moreno,
Wilson Bautista-Molano,
Consuelo Romero-Sánchez
Publication year - 2020
Publication title -
journal of clinical rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.615
H-Index - 50
eISSN - 1536-7355
pISSN - 1076-1608
DOI - 10.1097/rhu.0000000000001391
Subject(s) - medicine , rheumatoid arthritis , odds ratio , confidence interval , gastroenterology , radiological weapon , arthritis , rheumatoid factor , surgery
Rheumatoid arthritis (RA) is a systemic autoimmune disease that increased bone resorption. Periodontal disease (PD) is an associated risk factor of RA. Studies suggest an association between bone markers such as the dickkopf-related protein 1 (DKK-1) and progression of radiological damage. We aimed to evaluate the marker DKK-1, its polymorphisms in patients with early rheumatoid arthritis (eRA), and its association with rheumatic, radiological, and periodontal variables.