Open AccessCharacterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development
Author(s) -
Ana Palacios,
Rachel A. Feiner,
Robert M. Cabrera
Publication year - 2022
Publication title -
reproductive and developmental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.161
H-Index - 3
eISSN - 2589-8728
pISSN - 2096-2924
DOI - 10.1097/rd9.0000000000000034
Subject(s) - folinic acid , folate receptor , folic acid , biochemistry , methionine , receptor , chemistry , homocysteine , pharmacology , biology , amino acid , medicine , cancer cell , chemotherapy , cancer , genetics , fluorouracil
Folates are B vitamins that are essential for several molecular, cellular, and biological processes, including nucleotide synthesis, methylation, and methionine cycling. The physiological impacts of these processes on health also extend to cell proliferation, folate deficiency anemia, and reduction of the risk of birth defects during pregnancy. The primary objective of this study was to characterize the binding affinities of different folate forms, folic acid (FA), 5-methyltetrahydrofolate (5MTHF), and folinic acid, to the folate receptors α and β, and to the bovine milk folate binding protein. These three dietary forms of folate are found in enriched grains (FA), various fruits and leafy vegetables (folinic acid), and red blood cells (5MTHF).