Chronic HIV-Infected Patients Show an Impaired Dendritic Cells Differentiation of Bone Marrow CD34+ Cells | Zendy

Veronica Bordoni | Zendy; Michele Bibas | Zendy; Domenico Viola | Zendy; Alessandra Sacchi | Zendy; Chiara Agrati | Zendy; Germana Castelli | Zendy; Adriana Ammassari | Zendy; Alessandra Amendola | Zendy; Isabella Abbate | Zendy; Federico Martini | Zendy

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Chronic HIV-Infected Patients Show an Impaired Dendritic Cells Differentiation of Bone Marrow CD34+ Cells

Author(s) -

Veronica Bordoni,

Michele Bibas,

Domenico Viola,

Alessandra Sacchi,

Chiara Agrati,

Germana Castelli,

Adriana Ammassari,

Alessandra Amendola,

Isabella Abbate,

Federico Martini

Publication year - 2013

Publication title -

jaids journal of acquired immune deficiency syndromes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.162

H-Index - 157

eISSN - 1944-7884

pISSN - 1525-4135

DOI - 10.1097/qai.0b013e3182a40ff7

Subject(s) - bone marrow , cd34 , human immunodeficiency virus (hiv) , medicine , immunology , virology , biology , stem cell , microbiology and biotechnology

HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34⁺ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34⁺ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.

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