Open AccessChronic HIV-Infected Patients Show an Impaired Dendritic Cells Differentiation of Bone Marrow CD34+ Cells
Author(s) -
Veronica Bordoni,
Michele Bibas,
Domenico Viola,
Alessandra Sacchi,
Chiara Agrati,
Germana Castelli,
Adriana Ammassari,
Alessandra Amendola,
Isabella Abbate,
Federico Martini
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3182a40ff7
Subject(s) - bone marrow , cd34 , human immunodeficiency virus (hiv) , medicine , immunology , virology , biology , stem cell , microbiology and biotechnology
HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34⁺ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34⁺ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.