Open AccessNovel Role of HSP40/DNAJ in the Regulation of HIV-1 Replication
Author(s) -
Emiko Urano,
Yuko Morikawa,
Jun Komano
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31829a2ef8
Subject(s) - biology , viral replication , vaccinia , herpes simplex virus , virology , virus , genetics , gene , recombinant dna
DNAJ/HSP40 is an evolutionarily conserved family of proteins bearing various functions. Historically, it has been emphasized that HSP40/DNAJ family proteins play a positive role in infection of various viruses. We identified DNAJ/HSP40B6 as a potential negative regulator of HIV-1 replication in our genetic screens. In this study, we investigated the functional interactions between HIV-1 and HSP40 family members.