Novel Role of HSP40/DNAJ in the Regulation of HIV-1 Replication | Zendy

Emiko Urano | Zendy; Yuko Morikawa | Zendy; Jun Komano | Zendy

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Novel Role of HSP40/DNAJ in the Regulation of HIV-1 Replication

Author(s) -

Emiko Urano,

Yuko Morikawa,

Jun Komano

Publication year - 2013

Publication title -

jaids journal of acquired immune deficiency syndromes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.162

H-Index - 157

eISSN - 1944-7884

pISSN - 1525-4135

DOI - 10.1097/qai.0b013e31829a2ef8

Subject(s) - biology , viral replication , vaccinia , herpes simplex virus , virology , virus , genetics , gene , recombinant dna

DNAJ/HSP40 is an evolutionarily conserved family of proteins bearing various functions. Historically, it has been emphasized that HSP40/DNAJ family proteins play a positive role in infection of various viruses. We identified DNAJ/HSP40B6 as a potential negative regulator of HIV-1 replication in our genetic screens. In this study, we investigated the functional interactions between HIV-1 and HSP40 family members.

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