Open AccessSimian Immunodeficiency Virus Infection Potently Modulates Chemokine Networks and Immune Environments in Hilar Lymph Nodes of Cynomolgus Macaques
Author(s) -
Shulin Qin,
Beth Fallert Junecko,
Carissa M. Lucero,
Cynthia R. Klamar,
Anita Trichel,
Michael MurpheyCorb,
Patrick M. Tarwater,
Denise E. Kirschner,
Todd A. Reinhart
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31828ac85f
Subject(s) - biology , simian immunodeficiency virus , chemokine receptor , chemokine , immunology , cxcl10 , immune system , cxcr3 , c c chemokine receptor type 6 , virology
Chemokines provide critical immune cell homing and activation signals that if altered could affect the inflammatory milieu and cellular composition of lymphoid tissues. During HIV-1 and simian immunodeficiency virus (SIV)-infection, the virus triggers an increase in inflammation or activation, leading to immunodeficiency and development of opportunistic infections, such as in the lungs-a massive interface between the host and the environment.