Protein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy | Zendy

Kristine B. Patterson | Zendy; Julie B. Dumond | Zendy; Heather A. Prince | Zendy; Amanda J. Jenkins | Zendy; Kimberly K. Scarsi | Zendy; Ruili Wang | Zendy; Stephanie A. Malone | Zendy; Michael G. Hudgens | Zendy; Angela D. M. Kashuba | Zendy

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Protein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy

Author(s) -

Kristine B. Patterson,

Julie B. Dumond,

Heather A. Prince,

Amanda J. Jenkins,

Kimberly K. Scarsi,

Ruili Wang,

Stephanie A. Malone,

Michael G. Hudgens,

Angela D. M. Kashuba

Publication year - 2012

Publication title -

jaids journal of acquired immune deficiency syndromes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.162

H-Index - 157

eISSN - 1944-7884

pISSN - 1525-4135

DOI - 10.1097/qai.0b013e31827fd47e

Subject(s) - lopinavir , ritonavir , lopinavir/ritonavir , medicine , pregnancy , pharmacokinetics , gestation , prospective cohort study , obstetrics , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , immunology , biology , genetics

To investigate the intraindividual pharmacokinetics (PKs) of total (protein bound plus unbound) and unbound lopinavir/ritonavir (LPV/RTV) and to assess whether the pediatric formulation (100 mg/25 mg) can overcome any pregnancy-associated changes.

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