Open AccessProtein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy
Author(s) -
Kristine B. Patterson,
Julie Dumond,
Heather A. Prince,
Amanda J. Jenkins,
Kimberly K. Scarsi,
Ruili Wang,
Stephanie Malone,
Michael G. Hudgens,
Angela D. M. Kashuba
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31827fd47e
Subject(s) - lopinavir , ritonavir , lopinavir/ritonavir , medicine , pregnancy , pharmacokinetics , gestation , prospective cohort study , obstetrics , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , immunology , biology , genetics
To investigate the intraindividual pharmacokinetics (PKs) of total (protein bound plus unbound) and unbound lopinavir/ritonavir (LPV/RTV) and to assess whether the pediatric formulation (100 mg/25 mg) can overcome any pregnancy-associated changes.