Open AccessEfficient Mucosal Transmissibility but Limited Pathogenicity of R5 SHIVSF162P3N in Chinese-Origin Rhesus Macaques
Author(s) -
Alexandra Mumbauer,
Agegenhu Gettie,
James Blanchard,
Cecilia ChengMayer
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31827f1c11
Subject(s) - viremia , simian immunodeficiency virus , virology , rhesus macaque , transmission (telecommunications) , biology , virus , macaque , immunology , infectivity , viral load , paleontology , electrical engineering , engineering
Infection of rhesus macaques (RMs) of Indian origin with simian immunodeficiency virus or simian-HIV (SHIV) provided powerful tools to study HIV-1 transmission and disease and for testing the efficacy of novel drugs, vaccines, and prevention strategies. In developing alternative nonhuman primate AIDS models for the CCR5 (R5)-tropic SHIVSF162P3N, we characterized virus transmission and infection in Chinese-origin RMs.