Open AccessGenetic Variants in the Host Restriction Factor APOBEC3G are Associated With HIV-1–Related Disease Progression and Central Nervous System Impairment in Children
Author(s) -
Kumud K. Singh,
Yan Wang,
Kathryn P. Gray,
Mona Farhad,
Sean Brummel,
Terence Fenton,
Rodney Trout,
Stephen A. Spector
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31827ab612
Subject(s) - apobec3g , genotype , cytidine deaminase , biology , allele , immunology , genetics , virology , gene , antibody
Apolipoprotein B mRNA editing catalytic polypeptide 3G (APOBEC3G) protein is incorporated into nascent virus particles and mediates cytidine deamination (C-to-U) of first-strand reverse transcripts of HIV-1 in target cells resulting in G-to-A hypermutation of the coding strand and premature degradation. We investigated the effects of APOBEC3G genetic variants on HIV-1-related disease in children.