Genetic Variants in the Host Restriction Factor APOBEC3G are Associated With HIV-1–Related Disease Progression and Central Nervous System Impairment in Children | Zendy

Kumud K. Singh | Zendy; Yan Wang | Zendy; Kathryn P. Gray | Zendy; Mona Farhad | Zendy; Sean S. Brummel | Zendy; Terence Fenton | Zendy; Rodney Trout | Zendy; Stephen A. Spector | Zendy

Open Access

Genetic Variants in the Host Restriction Factor APOBEC3G are Associated With HIV-1–Related Disease Progression and Central Nervous System Impairment in Children

Author(s) -

Kumud K. Singh,

Yan Wang,

Kathryn P. Gray,

Mona Farhad,

Sean S. Brummel,

Terence Fenton,

Rodney Trout,

Stephen A. Spector

Publication year - 2012

Publication title -

jaids journal of acquired immune deficiency syndromes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.162

H-Index - 157

eISSN - 1944-7884

pISSN - 1525-4135

DOI - 10.1097/qai.0b013e31827ab612

Subject(s) - apobec3g , genotype , cytidine deaminase , biology , allele , immunology , genetics , virology , gene , antibody

Apolipoprotein B mRNA editing catalytic polypeptide 3G (APOBEC3G) protein is incorporated into nascent virus particles and mediates cytidine deamination (C-to-U) of first-strand reverse transcripts of HIV-1 in target cells resulting in G-to-A hypermutation of the coding strand and premature degradation. We investigated the effects of APOBEC3G genetic variants on HIV-1-related disease in children.

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